3,6-Dichloro-pyridazin-4-carboxylic acid methyl ester

3,6-Dichloro-pyridazin-4-carboxylic acid methyl ester - Names and Identifiers

Name	methyl 3,6-dichloropyridazine-4-carboxylate
Synonyms	150019 Methyl 3,6-dichloro-pyrid... Methyl 3,6-dichloropyridazine-3-carboxylate methyl 3,6-dichloropyridazine-4-carboxylate Methyl 3,6-dichloropyridazine-4-carboxylate 3,6-Dichloro-pyridazin-4-carboxylic acid methyl ester Methyl 3,6-dichloropyridazine-4-carboxylate, Fandachem 4-Pyridazinecarboxylic acid, 3,6-dichloro-, methyl ester
CAS	286946-24-5
EINECS	200-001-2

3,6-Dichloro-pyridazin-4-carboxylic acid methyl ester - Physico-chemical Properties

Molecular Formula	C6H4Cl2N2O2
Molar Mass	207.01
Density	1.503±0.06 g/cm3(Predicted)
Boling Point	357.3±37.0 °C(Predicted)
pKa	-3.63±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
MDL	MFCD12546173

3,6-Dichloro-pyridazin-4-carboxylic acid methyl ester - Reference Information

introduction

methyl 3,6-dichloropyridazine -4-carboxylic acid ethyl ester should be called 3,6-dichloropyridazine -4-methyl formate, which is a pharmaceutical intermediate, which can be composed of 3, 6-dichloro-4-carboxy-pyridazine and (trimethylsilyl) diazomethane are prepared in one step.

preparation method

to 3,6-dichloro-4-carboxyl-pyridazine (7.5g,38.9mmol, aldrich) of DCM(30mL) and MeOH(10mL) solutions are slowly added (trimethylsilyl) diazomethane (2.0M hexane solution) through a syringe until continuous yellow color is observed. After the addition is complete, the solvent is removed by vacuum. The crude product was purified by SiO2 chromatography and eluted with EtOAc/hexane gradient (10 to 25% EtOAc) to give 3.89g(86%) of brown oily methyl 3, 6-dichloropyridazine-4-formate, which solidified when standing.

Last Update：2024-04-09 20:49:11